SyntaxBomb - Indie Coders

Well here is a list of the software I use with AppGameKit Studio.
Blender
Audacity
mtPaint
Resource Hacker
Hook Folder Locker
7zip

So an extra 6 programs I had to get comfortable with.
mtPaint is very simple but does what I need .
Blender is going to take a couple weeks of practice to get going with, at first I hated it now I love it.
Resource hacker I use for changing the icons on my folders.
7z is for packaging
Hook Folder Locker is for a little protection of my media file.
Audacity for my sounds although I did buy a sound pack from TGC which is not bad. 
There we are all the programs here are free. 

I second mtPaint, a good not overly complicated graphics application.

Also cross-platform and open source too!

i use :
-fragmotion to make 3d models ( modeling, uvmaping, rigging, skinning, animating )
-photofiltre 7 to make 2d images / textures
-wavepad editor to edit sounds

I have been using mtPaint for a long time and the only complaint is no basic shapes, but it's still very nice and simple and gets the job done. I've tried a few programs like mtPaint but just didn't take to them.